Article last reviewed by Thu 22 March However, white spots can also be caused by some sexually transmitted diseases STDs and may require treatment. Exercise boosts well-being by improving gut health. Pimples are small fluid filled pustules that usually are caused as a result of an infection Multiple pimples on penis inflammation of the hair follicles. Genital warts are a caused by a STD Multiple pimples on penis may develop after a person has come into contact with the human papillomavirus HPV. The blisters can become open sores and ooze fluids and will crust over.